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Contraindicated (one)pentobarbital will reduce the level or influence of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.Watch Carefully (two)pentobarbital will lessen the extent or result of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Powerful CYP3A4 inducers may well reduce suvore